Below is a map of Central Asia border crossings from Caravanistan.com, super helpful information. We originally plan to cross the border between Uzbekistan and Tajikistan through Penjikent but found that it had been closed since 2011 due to civil unrest. Click here for the full map.
Green: no problem
Yellow: possible problems
Azure: Bilateral border crossing: only for residents of the 2 countries of the border crossing.
Purple: not enough information
Blue: other border crossings on the Silk road. Not researched and updated.